How lithium went from 7Up to treatment for mental illness — and maybe Alzheimer’s A new study suggests lithium may play a crucial role in developing Alzheimer’s treatments, but the substance has long been used to treat mood disorders like bipolar disorder. Today at 6:00 a.m. EDT
Liviu Aron looks at samples of human and mouse brains in a Harvard research lab. (Heather Diehl/Boston Globe/Getty Images) A study this week in the journal Nature found that the loss of lithium, a naturally occurring element in the brain, could be an early sign of Alzheimer’s and a powerful driver of the disease, which afflicts more than 7 million Americans. The study, led by Bruce A. Yankner, a professor of genetics and neurology at Harvard Medical School, found that lithium is important to the health of all the major types of brain cells in mice. Depletion of lithium in the brain also seems to be a factor in almost all of the major deterioration that occurs with Alzheimer’s disease. While the latest study of lithium is novel in pointing toward a potential Alzheimer’s treatment, the use of lithium to treat other conditions is not. Here’s a look at what it has worked for and how its use is being researched in new ways. What is lithium? Return to menu Lithi...


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